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Journal of Clinical Microbiology, April 2007, p. 1333-1335, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02422-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Deletion of fetA Gene Sequences in Serogroup B and C Neisseria meningitidis Isolates{triangledown}

Jane W. Marsh,1* Mary M. O'Leary,1,2 Kathleen A. Shutt,1 and Lee H. Harrison1

Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania,1 Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania2

Received 1 December 2006/ Returned for modification 23 January 2007/ Accepted 30 January 2007

The immunogenic iron-regulated FetA outer membrane protein of Neisseria meningitidis is one of various outer membrane proteins that have been considered potential meningococcal vaccine candidates. In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements.

* Corresponding author. Mailing address: University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261. Phone: (412) 648-3102. Fax: (412) 648-8455. E-mail: marshj{at}dom.pitt.edu

{triangledown} Published ahead of print on 7 February 2007.

Journal of Clinical Microbiology, April 2007, p. 1333-1335, Vol. 45, No. 4
0095-1137/07/$08.00+0     doi:10.1128/JCM.02422-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Claus, H., Elias, J., Meinhardt, C., Frosch, M., Vogel, U. (2007). Deletion of the Meningococcal fetA Gene Used for Antigen Sequence Typing of Invasive and Commensal Isolates from Germany: Frequencies and Mechanisms. J. Clin. Microbiol. 45: 2960-2964 [Abstract] [Full Text]  


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