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Journal of Clinical Microbiology, May 2007, p. 1515-1522, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.02189-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Multiple Genotypes of Influenza B Viruses Cocirculated in Taiwan in 2004 and 2005{triangledown}

Guang-Wu Chen,1,2,5,{dagger} Shin-Ru Shih,1,3,4,5,{dagger} Mei-Ren Hsiao,3,4 Shih-Cheng Chang,1,3,4,5 Shu-Hung Lin,2 Chien-Fen Sun,3,4 and Kuo-Chien Tsao1,3,4,5*

Research Center for Emerging Viral Infections,1 Department of Computer Science & Information Engineering,2 Department of Medical Biotechnology & Laboratory Science, Chang Gung University,3 Clinical Virology Laboratory, Department of Clinical Pathology,4 Chang Gung Memorial Hospital, Taoyuan, Taiwan5

Received 26 October 2006/ Returned for modification 18 December 2006/ Accepted 19 February 2007

An influenza B outbreak occurred in Taiwan in 2004 and 2005, during which both Victoria (Vic) and Yamagata (Ya) lineages cocirculated. This study examined 36 influenza B viral genomes isolated during the outbreak to reveal their reassortment patterns. According to the isolate groupings in phylogenetic analysis, we were able to categorize those 36 isolates as being of either the Victoria or Yamagata lineage for all eight influenza B virus genomic segments, except for the NS gene, in which clades A and B existed. Based on these groupings, three genome patterns clearly emerged, namely, pattern I (Vic+Vic+Ya+Vic+Ya+Ya+Ya+A, from segments 1 to 8), pattern II (Ya+Ya+Ya+Ya+Ya+Ya+Ya+B), and pattern III (Ya+Ya+Ya+Ya+Ya+Ya+Ya+A). According to the timeline of those isolates under investigation, it appears that pattern I and II viruses could have generated pattern III via reassortment of the NS gene. On the other hand, a genomewide comparison of all six pattern III Taiwanese viruses with 37 international influenza B viral genomes showed that two international strains, B/Oslo/71/04 and B/England/23/04, were consistently clustered with the pattern III viruses isolated in Taiwan in 2004 and 2005, suggesting that Taiwanese pattern III viruses might also have been imported due to their matching genomic composition.

* Corresponding author. Mailing address: Department Clinical Pathology, Chang Gung Memorial Hospital, no. 5, Fu-Hsing Street, Kwei-Shan, Taoyuan, 333 Taiwan. Phone: 886-3-3281200, ext. 2523. Fax: 886-3-2118174. E-mail: kctsao{at}adm.cgmh.org.tw

{triangledown} Published ahead of print on 28 February 2007.

{dagger} G.-W.C. and S.-R.S. contributed equally to this work.

Journal of Clinical Microbiology, May 2007, p. 1515-1522, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.02189-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jian, J.-W., Chen, G.-W., Lai, C.-T., Hsu, L.-C., Chen, P.-J., Kuo, S. H.-S., Wu, H.-S., Shih, S.-R. (2008). Genetic and Epidemiological Analysis of Influenza Virus Epidemics in Taiwan during 2003 to 2006. J. Clin. Microbiol. 46: 1426-1434 [Abstract] [Full Text]  


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