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Journal of Clinical Microbiology, May 2007, p. 1614-1617, Vol. 45, No. 5
0095-1137/07/$08.00+0     doi:10.1128/JCM.00032-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Novel Human Rotavirus of Genotype G5P[6] Identified in a Stool Specimen from a Chinese Girl with Diarrhea

Zhao-Jun Duan,^1,* Dan-Di Li,^1,2, Qing Zhang,¹ Na Liu,¹ Can-Ping Huang,¹ Xi Jiang,³ Baomin Jiang,⁴ Roger Glass,⁴ Duncan Steele,⁵ Jing-Yu Tang,⁶ Zhong-Shan Wang,² and Zhao-Yin Fang¹

National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China,¹ School of Basic Medical Sciences of Jilin University, Changchun 130021, China,² Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio,³ Centers for Disease Control and Prevention, Atlanta, Georgia,⁴ World Health Organization, Geneva, Switzerland,⁵ Hebei Province Center for Disease Control and Prevention, Lulong County, China⁶

Received 5 January 2007/ Returned for modification 6 February 2007/ Accepted 8 February 2007

During a rotavirus surveillance conducted in Lulong County, Hebei Province, China, a total of 331 stool specimens collected in 2003 from children under 5 years old with diarrhea were screened. We identified a novel group A human rotavirus of genotype G5P[6]. Phylogenetic analysis confirmed that the VP7 protein of this newly identified strain, LL36755, was closely related to those of the G5 strains. As such, it has 95.4% homology with its counterparts in the porcine G5 strains C134 and CC117 at the amino acid sequence level. On the other hand, the VP4 protein of the LL36755 strain was 94.5% homologous to those of the porcine P[6] strains 134/04-10, 134/04-11, 221/04-7, and 221/04-13. Our findings indicate a dynamic interaction between human and porcine rotaviruses.

Published ahead of print on 14 February 2007.

Dan-Di Li and Zhao-Jun Duan contributed to this work equally.

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