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Exceptionally High Representation of Burkholderia cepacia among B. cepacia Complex Isolates Recovered from the Major Portuguese Cystic Fibrosis Center

IBB—Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal,¹ Instituto de Microbiologia, Faculdade de Medicina da Universidade de Coimbra, Rua Larga, 3004-504 Coimbra, Portugal,² Direcção de Comprovação da Qualidade do Infarmed, Parque de Saúde de Lisboa, Avenida do Brasil, no. 53, 1749-004 Lisboa, Portugal,³ Laboratório de Bacteriologia,⁴ e Centro Especializado em Fibrose Quística, Hospital de Santa Maria, Av. Prof. Egas Moniz, Lisboa, Portugal⁵

Received 30 January 2007/ Returned for modification 2 March 2007/ Accepted 7 March 2007

Burkholderia cepacia, a species found infrequently in cystic fibrosis (CF), was isolated from 85% of patients infected with bacteria of the B. cepacia complex that visited the major Portuguese CF center, in Lisbon, during 2003 to 2005. A detailed molecular analysis revealed that this was mainly due to two B. cepacia clones. These clones were indistinguishable from two strains isolated from intrinsically contaminated nonsterile saline solutions for nasal application, detected during routine market surveillance by the Portuguese Medicines and Health Products Authority.

Published ahead of print on 14 March 2007.

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