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Journal of Clinical Microbiology, June 2007, p. 1753-1758, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02134-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genetic and Antigenic Analysis of Invasive Serogroup Y Neisseria meningitidis Isolates Collected from 1999 to 2003 in Canada{triangledown} ,{dagger}

Raymond S. W. Tsang,1* Averil M. Henderson,1 Marissa L. Cameron,1 Shaun D. Tyler,2 Shari Tyson,2 Dennis K. S. Law,1 Jan Stoltz,1 and Wendell D. Zollinger3

Laboratory for Vaccine Preventable Bacterial Diseases,1 DNA Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada,2 Department of Bacterial Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland3

Received 17 October 2006/ Returned for modification 8 January 2007/ Accepted 9 April 2007

One hundred forty serogroup Y Neisseria meningitidis isolates recovered from patients with invasive meningococcal disease (IMD) in Canada from 1999 to 2003 were analyzed by genetic and serological methods. Seventy-four isolates (52.9%) belonged to serotype 2c, and most have serosubtype antigen P1.5,2 (37 isolates, 26%) or P1.5 (31 isolates, 22%). Forty-eight isolates (34.3%) belonged to serotype 14 and have serosubtype antigen P1.5,2 (13 isolates, 9%) or P1.5 (7 isolates, 5%) or were nonserosubtypeable (27 isolates, 19%). Thirteen isolates (9.3%) were nonserotypeable. Multilocus sequence typing identified two unrelated clonal populations of serogroup Y meningococci causing invasive disease in Canada: ST-23 and ST-167 clonal complexes. Almost all ST-167-related isolates were typed as 2c:P1.5, while strains of the ST-23 clonal complex were either serotype 14 or 2c but with the serosubtype antigen P1.5,2. In contrast to previous reports that patients with serogroup Y disease are usually older, 26% of the Canadian serogroup Y cases were found in the 10-to-19-year-old age group and another 11% were in the 20-to-39-year-old age group.

* Corresponding author. Mailing address: Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2. Phone: (204) 789-6020. Fax: (204) 789-2018. E-mail: Raymond_Tsang{at}phac-aspc.gc.ca

{triangledown} Published ahead of print on 18 April 2007.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, June 2007, p. 1753-1758, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02134-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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