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Journal of Clinical Microbiology, June 2007, p. 1996-1999, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.00612-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Nucleotide Sequence Diversity of the bexA Gene in Serotypeable Haemophilus influenzae Strains Recovered from Invasive Disease Patients in Canada{triangledown} ,{dagger}

Jianwei Zhou, Dennis K. S. Law, Michelle L. Sill, and Raymond S. W. Tsang*

Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

Received 20 March 2007/ Returned for modification 6 April 2007/ Accepted 16 April 2007

The bexA genes of 36 Haemophilus influenzae isolates were sequenced to reveal their nucleotide sequence diversity, which divided them into two groups, similar to clonal divisions I and II. This sequence diversity may lead to false-negative PCR results for H. influenzae infections if bexA is the chosen gene target.


* Corresponding author. Mailing address: National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington St., Winnipeg, Manitoba, Canada R3E 32R2. Phone: (204) 789-6020. Fax: (204) 789-2018. E-mail: raymond_tsang{at}phac-aspc.gc.ca

{triangledown} Published ahead of print on 25 April 2007.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.


Journal of Clinical Microbiology, June 2007, p. 1996-1999, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.00612-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.







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