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Journal of Clinical Microbiology, June 2007, p. 2034-2036, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02538-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Metallo-ß-Lactamase or Extended-Spectrum ß-Lactamase: a Wolf in Sheep's Clothing{triangledown}

Björn A. Espedido, Lee C. Thomas, and Jonathan R. Iredell*

Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia

Received 19 December 2006/ Returned for modification 20 February 2007/ Accepted 23 March 2007

Diagnostic algorithms in commonly used automated bacterial identification systems fail to reliably identify a metallo-ß-lactamase in the Enterobacteriaceae. Misidentification as an extended-spectrum ß-lactamase may result in inappropriate dismissal of drugs such as aztreonam in favor of carbapenems, which may in turn select for a highly carabapenem resistant phenotype.


* Corresponding author. Mailing address: Centre for Infectious Diseases and Microbiology, Level 3 ICPMR Building, Westmead Hospital, Westmead, NSW 2145, Australia. Phone: 612-9845-6255. Fax: 612-9891-5317. E-mail: joni{at}icpmr.wsahs.nsw.gov.au

{triangledown} Published ahead of print on 4 April 2007.


Journal of Clinical Microbiology, June 2007, p. 2034-2036, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.02538-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.




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