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Journal of Clinical Microbiology, June 2007, p. 2054-2057, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.01519-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Molecular Epidemiology and Clinical Manifestations of Viral Gastroenteritis in Hospitalized Pediatric Patients in Northern Taiwan{triangledown}

Shih-Yen Chen,1,6 Yu-Chung Chang,2 Yun-Shien Lee,2,3 Hsun-Chin Chao,1 Kuo-Chien Tsao,4 Tzou-Yien Lin,5 Tzu-Yin Ko,6 Chi-Neu Tsai,6* and Cheng-Hsun Chiu5*

Division of Pediatric Gastroenterology, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan,1 Department of Biotechnology, Ming-Chuan University, Taoyuan, Taiwan,2 Genomic Medical Research Core Lab,3 Department of Clinical Pathology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan,4 Division of Pediatric Infectious Diseases, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan,5 Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taoyuan, Taiwan6

Received 24 July 2006/ Returned for modification 22 October 2006/ Accepted 21 March 2007

By reverse transcription-PCR or PCR, among 257 children with nonbacterial acute gastroenteritis (AGE), rotavirus, norovirus, astrovirus, enteric adenovirus, and multiple viruses were identified in 78 (30.4%), 21 (8.2%), 7 (2.7%), 51 (19.8%), and 53 (20.6%) patients, respectively. Higher disease severity was found for AGE caused by multiple viruses and by rotavirus alone. The majority of rotaviruses isolated from 2004 to 2006 belonged to genotypes G1 (20.4%), G2 (16.5%), G3 (27.2%), and G9 (21.4%).

* Corresponding author. Mailing address for Chi-Neu Tsai: Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, 259 Wen-Hua 1st Road, Kweishan 333, Taoyuan, Taiwan. Mailing address for Cheng-Hsun Chiu: Chang Gung Children's Hospital, 5 Fu-Hsin Street, Kweishan 333, Taoyuan, Taiwan. Phone: 886 3 3281200. Fax: 886 3 3288957. E-mail: chchiu{at}adm.cgmh.org.tw

{triangledown} Published ahead of print on 18 April 2007.

Journal of Clinical Microbiology, June 2007, p. 2054-2057, Vol. 45, No. 6
0095-1137/07/$08.00+0     doi:10.1128/JCM.01519-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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