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Journal of Clinical Microbiology, July 2007, p. 2263-2266, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.02354-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evidence that the Spread of Mycobacterium tuberculosis Strains with the Beijing Genotype Is Human Population Dependent{triangledown}

M. Hanekom, G. D. van der Spuy, N. C. Gey van Pittius, C. R. E. McEvoy, S. L. Ndabambi, T. C. Victor, E. G. Hoal, P. D. van Helden, and R. M. Warren*

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa

Received 21 November 2006/ Returned for modification 30 March 2007/ Accepted 23 April 2007

This study describes a comparative analysis of the Beijing mycobacterial interspersed repetitive unit types of Mycobacterium tuberculosis isolates from Cape Town, South Africa, and East Asia. The results show a significant association between the frequency of occurrence of strains from defined Beijing sublineages and the human population from whom they were cultured (P < 0.0001).

* Corresponding author. Mailing address: DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 021 938 9073. Fax: 021 938 9476. E-mail: rw1{at}sun.ac.za

{triangledown} Published ahead of print on 2 May 2007.

Journal of Clinical Microbiology, July 2007, p. 2263-2266, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.02354-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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