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Journal of Clinical Microbiology, July 2007, p. 2296-2297, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.02168-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Insertion Sequence 1515 in the ply Gene of a Type 1 Clinical Isolate of Streptococcus pneumoniae Abolishes Pneumolysin Expression{triangledown}

Fabien Garnier,1* Rajendra Prasad Janapatla,2 Emmanuelle Charpentier,2 Geoffrey Masson,1 Carole Grélaud,1 Jean François Stach,3 François Denis,1 and Marie-Cécile Ploy1

Laboratoire de Bactériologie-Virologie-Hygiène, CHU Dupuytren, EA 3175, Limoges, France,1 Max F. Perutz Laboratories, University of Vienna, Vienna, Austria,2 Laboratoire de Microbiologie, Centre Hospitalier de Guéret, Guéret, France3

Received 24 October 2006/ Returned for modification 5 February 2007/ Accepted 1 May 2007

A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S. pneumoniae.

* Corresponding author. Mailing address: Laboratoire de Bactériologie-Virologie-Hygiène, EA 3175, CHU DUPUYTREN, 2 avenue Martin Luther King, 87042 Limoges cedex, France. Phone: 33 555 05 63 48. Fax: 33 555 05 67 22. E-mail: fabien.garnier{at}unilim.fr

{triangledown} Published ahead of print on 9 May 2007.

Journal of Clinical Microbiology, July 2007, p. 2296-2297, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.02168-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Martner, A., Dahlgren, C., Paton, J. C., Wold, A. E. (2008). Pneumolysin Released during Streptococcus pneumoniae Autolysis Is a Potent Activator of Intracellular Oxygen Radical Production in Neutrophils. Infect. Immun. 76: 4079-4087 [Abstract] [Full Text]  


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