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Journal of Clinical Microbiology, July 2007, p. 2316-2320, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.00203-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

PCR-Restriction Fragment Length Polymorphism Analysis of Campylobacter jejuni Genes Involved in Lipooligosaccharide Biosynthesis Identifies Putative Molecular Markers for Guillain-Barré Syndrome

Peggy C. R. Godschalk,^1* Alex van Belkum,¹ Nicole van den Braak,^1, Diana van Netten,¹ C. Wim Ang,^1, Bart C. Jacobs,^2,3 Michel Gilbert,⁴ and Hubert P. Endtz¹

Departments of Medical Microbiology and Infectious Diseases,¹ Immunology,² Neurology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands,³ Institute for Biological Sciences, National Research Council Canada, Ottawa, Canada⁴

Received 26 January 2007/ Returned for modification 18 March 2007/ Accepted 8 May 2007

Molecular mimicry of Campylobacter jejuni lipooligosaccharides (LOS) by gangliosides in peripheral nerve tissue probably triggers the Guillain-Barré syndrome due to the induction of cross-reactive antibodies. PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy.

Published ahead of print on 16 May 2007.

Present address: Avans University, Breda, The Netherlands.

Present address: Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands.

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