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Journal of Clinical Microbiology, July 2007, p. 2340-2343, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.00364-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Diagnosis of a Critical Respiratory Illness Caused by Human Metapneumovirus by Use of a Pan-Virus Microarray{triangledown}

Charles Y. Chiu,1,3,4 Ash A. Alizadeh,7,8 Silvi Rouskin,1 Jason D. Merker,6 Elaine Yeh,10 Shigeo Yagi,10 David Schnurr,10 Bruce K. Patterson,6,7,9 Don Ganem,2,3,4,5 and Joseph L. DeRisi1,3,5*

Departments of Biochemistry and Biophysics,1 Microbiology,2 Medicine,3 Division of Infectious Diseases,4 Howard Hughes Medical Institute, University of California, San Francisco, California,5 Departments of Pathology,6 Medicine,7 Divisions of Hematology,8 Infectious Diseases and Geographic Medicine, Stanford School of Medicine, Palo Alto, California,9 Viral and Rickettsial Disease Laboratory, California Department of Health Services, Richmond, California,10

Received 15 February 2007/ Returned for modification 6 April 2007/ Accepted 26 April 2007

A pan-virus DNA microarray (Virochip) was used to detect a human metapneumovirus (hMPV) strain associated with a critical respiratory tract infection in an elderly adult with chronic lymphocytic leukemia. This infection had previously eluded diagnosis despite extensive microbiological testing for possible etiologic agents. The patient's hMPV strain did not grow in viral culture, and only one of five specific reverse transcription-PCR assays for hMPV was positive.

* Corresponding author. Mailing address: Department of Biochemistry and Biophysics, University of California, San Francisco at Mission Bay, office BH403C, QB3 building, 1700 4th Street, San Francisco CA 94158. Phone: (415) 476-4132. Fax: (415) 514-2073. E-mail: joe{at}derisilab.ucsf.edu

{triangledown} Published ahead of print on 9 May 2007.

Journal of Clinical Microbiology, July 2007, p. 2340-2343, Vol. 45, No. 7
0095-1137/07/$08.00+0     doi:10.1128/JCM.00364-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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