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Journal of Clinical Microbiology, August 2007, p. 2734-2736, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00479-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Shelf Life of Predosed Plates Containing Mefloquine, Artemisinin, Dihydroartemisinin, and Artesunate as Used for In Vitro Plasmodium falciparum Susceptibility Assessment{triangledown}

Sandrine Houzé,1* Aline Munier,1,{dagger} Xavier Paoletti,2 Halima Kaddouri,1 Pascal Ringwald,3 and Jacques Le Bras1

Laboratoire de Parasitologie, Centre National de Référence du Paludisme, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, and Université Paris Descartes, EA 209, Paris, France,1 Département d'Epidémiologie, de Biostatistique et de Recherche Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France,2 World Health Organization, 1211 Geneva 27, Switzerland3

Received 3 March 2007/ Returned for modification 17 April 2007/ Accepted 30 May 2007

The shelf lives of preserved antimalarial agent-predosed plates according to the type of wrapping and the temperature of storage were studied by measuring the 50% inhibitory concentrations of drug for Plasmodium falciparum 3D7. The shelf life of mefloquine was 8 weeks at 25°C; and those of artesunate, artemisinin, and dihydroartemisinin were a minimum of 24, 12, and 8 weeks, respectively, at 4°C.

* Corresponding author. Mailing address: Laboratoire de Parasitologie, CNR Paludisme, Hôpital Bichat-Claude Bernard, 46, Rue Henri Huchard, 75877 Paris Cedex 18, France. Phone: (331) 40257881. Fax: (331) 40256763. E-mail: sandrine.houze{at}bch.aphp.fr

{triangledown} Published ahead of print on 6 June 2007.

{dagger} Present address: IRD UR 009, Dakar, Senegal.

Journal of Clinical Microbiology, August 2007, p. 2734-2736, Vol. 45, No. 8
0095-1137/07/$08.00+0     doi:10.1128/JCM.00479-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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