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Journal of Clinical Microbiology, January 2008, p. 206-213, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01414-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Epidemiological, Molecular, and Clinical Features of Enterovirus Respiratory Infections in French Children between 1999 and 2005{triangledown}

Jérôme Jacques,1,2 Hélène Moret,1,2 Delphine Minette,3 Nicolas Lévêque,1,2 Nicolas Jovenin,5 Gaetan Deslée,4 François Lebargy,4 Jacques Motte,3 and Laurent Andréoletti1,2*

Laboratoire de Virologie, Centre Hospitalier Universitaire,1 IFR 53/EA-3798 (DAT/PPCIDH), Faculté de Médecine,2 Service de Pédiatrie A, Unité INSERM 666 et Faculté de Médecine,3 Service de Pneumologie, Centre Hospitalier Universitaire et Faculté de Médecine,4 Département d'Information Médicale, Centre Hospitalier Universitaire et Faculté de Médecine de Reims, Reims, France5

Received 14 July 2007/ Returned for modification 23 October 2007/ Accepted 29 October 2007

Enteroviruses (EVs) can induce nonspecific respiratory tract infections in children, but their epidemiological, virological, and clinical features remain to be assessed. In the present study, we analyzed 252 EV-related infection cases (median age of subjects, 5.1 years) diagnosed among 11,509 consecutive children visiting emergency departments within a 7-year period in the north of France. EV strains were isolated from nasopharyngeal samples by viral cell culture, identified by seroneutralization assay, and genetically compared by partial amplification and sequencing of the VP1 gene. The respiratory syndromes (79 [31%] of 252 EV infections) appeared as the second most common EV-induced pediatric pathology after meningitis (111 [44%] of 252 cases) (44 versus 31%, P < 10–3), contributing to lower respiratory tract infection (LRTI) in 43 (54%) of 79 EV respiratory infection cases. Bronchiolitis was the most common EV-induced LRTI (34 [43%] of 79 cases, P < 10–3) occurring more often in infants aged 1 to 12 months (P = 0.0002), with spring-fall seasonality. Viruses ECHO 11, 6, and 13 were the more frequently identified respiratory strains (24, 13, and 11%, respectively). The VP1 gene phylogenetic analysis showed the concomitant or successive circulation of genetically distinct EV respiratory strains (species A or B) during the same month or annual epidemic period. Our findings indicated that respiratory tract infections accounted for the 30% of EV-induced pediatric pathologies, contributing to LRTIs in 54% of these cases. Moreover, the concomitant or successive circulation of genetically distinct EV strains indicated the possibility of pediatric repeated respiratory infections within the same epidemic season.

* Corresponding author. Mailing address: Laboratoire de Virologie, Service de Microbiologie, Hôpital Robert Debré, Avenue du Général Koenig, 51092 REIMS Cedex, France. Phone: (33) 3 26 78 39 93. Fax: (33) 3 26 78 41 34. E-mail: landreoletti{at}chu-reims.fr

{triangledown} Published ahead of print on 14 November 2007.

Journal of Clinical Microbiology, January 2008, p. 206-213, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01414-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Blomqvist, S., Paananen, A., Savolainen-Kopra, C., Hovi, T., Roivainen, M. (2008). Eight Years of Experience with Molecular Identification of Human Enteroviruses. J. Clin. Microbiol. 46: 2410-2413 [Abstract] [Full Text]  


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