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"Mid-G" Region Sequences of the Glycoprotein Gene of Austrian Infectious Hematopoietic Necrosis Virus Isolates Form Two Lineages within European Isolates and Are Distinct from American and Asian Lineages

Zoonoses and Emerging Infections Group, Clinical Virology, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, and Clinic for Avian, Reptile, and Fish Medicine,¹ Clinical Department for Farm Animals and Herd Health Management, University of Veterinary Medicine, Vienna, A-1210 Vienna, Austria,² Impfstoffwerk Dessau-Tornau GmbH, Rodleben, Germany³

Received 14 March 2007/ Returned for modification 29 July 2007/ Accepted 21 October 2007

Infectious hematopoietic necrosis virus (IHNV) is one of the most important pathogens of salmonid fish. In this study a comprehensive phylogenetic analysis of the genetic evolution and variety of Austrian IHNV strains, as well as selected strains ensuring worldwide coverage, is presented. The phylogenetic investigation is based on sequences comprising the "mid-G" region of the G gene, and it includes all currently available IHNV sequences of the G gene with a length of at least 615 bp. Austrian IHNVs are located—together with other European IHNV isolates—in two clusters of genogroup M (M-Eur1 and M-Eur2) and are clearly separated from American and Asian lineages. The genetic clustering, however, could not be linked to certain clinical symptoms or significant differences in the mortality rates.

Published ahead of print on 31 October 2007.