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Identification of Adenoviruses in Specimens from High-Risk Pediatric Stem Cell Transplant Recipients and Controls

Xiaotian Zheng,^1,3* Xiaoyan Lu,⁴ Dean D. Erdman,⁴ Evan J. Anderson,^1,2,3 Judith A. Guzman-Cottrill,^1, Morris Kletzel,^1,3 and Ben Z. Katz^1,3

Children's Memorial Hospital,¹ Northwestern Memorial Hospital,² Feinberg School of Medicine, Northwestern University, Chicago, Illinois,³ Centers for Disease Control and Prevention, Atlanta, Georgia⁴

Received 9 August 2007/ Returned for modification 26 August 2007/ Accepted 25 October 2007

Adenovirus infection is an important cause of morbidity and mortality in stem cell transplant recipients. We report species and type-specific analysis from a prospective study of high-risk adenovirus infections following hematopoietic progenitor cell transplantation prior to, during, and after treatment with cidofovir, as well as species analysis of contemporaneously collected samples from control patients. Nine different adenovirus types representing all six recognized species were identified, and mixed infections were commonly found in this group of patients.

Published ahead of print on 7 November 2007.

Present address: Oregon Health and Science University, Portland, OR.