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Journal of Clinical Microbiology, January 2008, p. 325-327, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01735-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Novel Varicella-Zoster Virus Glycoprotein E Gene Mutations Associated with Genotypes A and D{triangledown}

Jonas Schmidt-Chanasit,1,2* Karoline Bleymehl,1 Susanne G. Schäd,3 Gerd Gross,3 Rainer G. Ulrich,4 and Hans Wilhelm Doerr1

Institute of Medical Virology, Hospital of the Johann Wolfgang Goethe University, D-60596 Frankfurt am Main,1 Bernhard-Nocht-Institute for Tropical Medicine, Clinical Virology Laboratory, D-20359 Hamburg,2 Department of Dermatology and Venereology, University of Rostock, D-18055 Rostock,3 Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute for Novel and Emerging Infectious Diseases, D-17493 Greifswald, Germany4

Received 31 August 2007/ Returned for modification 7 November 2007/ Accepted 9 November 2007

Here, we describe the association of certain varicella-zoster virus (VZV) genotypes with unique glycoprotein E (gE) gene mutations. Within 45 analyzed VZV wild-type strains of genotypes A and D, five novel gE mutations were discovered. A statistically significant (P < 0.0001) association of certain gE mutations with VZV genotype D was found.

* Corresponding author. Mailing address: Bernhard-Nocht-Institute for Tropical Medicine, Clinical Virology Laboratory, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany. Phone: 49-40-42818-205. Fax: 49-40-42818-400. E-mail: jonassi{at}gmx.de

{triangledown} Published ahead of print on 21 November 2007.

Journal of Clinical Microbiology, January 2008, p. 325-327, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01735-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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