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High Rate of Human Bocavirus and Adenovirus Coinfection in Hospitalized Israeli Children

Musa Y. Hindiyeh,^1* Nathan Keller,² Michal Mandelboim,¹ Daniela Ram,¹ Jana Rubinov,¹ Liora Regev,¹ Virginia Levy,¹ Sara Orzitzer,¹ Hilda Shaharabani,¹ Roberto Azar,¹ Ella Mendelson,^1,3, and Zehava Grossman^1,

Central Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel-Hashomer, Israel,¹ Department of Clinical Microbiology, Sheba Medical Center, Tel-Hashomer, Israel,² Faculty of Life Sciences, Bar Ilan University, Ramat-Gan, Israel³

Received 14 August 2007/ Returned for modification 24 September 2007/ Accepted 17 October 2007

We investigated coinfection of human bocavirus (HBoV) and other respiratory viruses in hospitalized children by real-time PCR. A high rate (69.2%) of adenovirus infection was found among children infected with HBoV. Such high rates of HboV-adenovirus coinfection have not been previously reported, underscoring the need to investigate the contribution of HBoV in patient clinical presentations.

Published ahead of print on 31 October 2007.

E.M. and Z.G. contributed equally.