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Comparison of the Human Immunodeficiency Virus (HIV) Type 1-Specific Immunoglobulin G Capture Enzyme-Linked Immunosorbent Assay and the Avidity Index Method for Identification of Recent HIV Infections

Stephan Loschen,¹ Jörg Bätzing-Feigenbaum,² Gabriele Poggensee,² Christiane Cordes,³ Bettina Hintsche,⁴ Michael Rausch,⁵ Stephan Dupke,⁶ Silvia Gohlke-Micknis,² Jana Rödig,^1, Osamah Hamouda,² and Claudia Kücherer^1*

Project HIV Variability and Molecular Epidemiology, Robert Koch-Institut, Berlin, Germany,¹ Dept. HIV/AIDS and STI, Robert Koch-Institut, Berlin, Germany,² Medical Practice, Gubener Strasse 37, 10243 Berlin, Germany,³ Medical Practice, Friedrichstrasse 113a, 10117 Berlin, Germany,⁴ Medical Practice, Fuggerstrasse 19, 10777 Berlin, Germany,⁵ Medical Practice, Driesenerstrasse 11, 10439 Berlin, Germany⁶

Received 23 May 2007/ Returned for modification 7 September 2007/ Accepted 24 October 2007

The sensitivity and specificity of the human immunodeficiency virus (HIV) type 1-specific immunoglobulin G capture enzyme-linked immunosorbent assay (BED-CEIA) were compared with those of the avidity index method to identify recent HIV infection using a panel of 148 samples (81 patients) representing durations of infection ranging from 0 to 222 weeks. The results from the two tests were similar (sensitivity of 80% versus 74% [P = 0.53]; specificity of 86% versus 82% [P = 0.67]).

Published ahead of print on 31 October 2007.

Present address: Dept. Developemental Biology, Institute de Génétique et de Biologie Moléculaire et Céllulaire, Illkirch Cedex, France.