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Journal of Clinical Microbiology, January 2008, p. 361-365, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01561-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Emergence of Fluoroquinolone-Resistant Haemophilus influenzae Strains among Elderly Patients but Not among Children{triangledown}

Shin-ichi Yokota,1 Yasuo Ohkoshi,1,2 Kiyoshi Sato,1 and Nobuhiro Fujii1*

Department of Microbiology, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan,1 Hokkaido Laboratory, SRL Co., Ltd., Chuo-ku, Sapporo 064-0919, Japan2

Received 6 August 2007/ Accepted 22 October 2007

We screened 457 Haemophilus influenzae strains isolated in Japan during 2002 to 2004 and identified 12 fluoroquinolone-resistant strains (2.6%). The resistant strains were divided into three genotypes (eight, three, and one of each type). These were isolated from patients over 58 years of age. Several fluoroquinolone-resistant clones appeared to have invaded the population of elderly patients in a particular area, Sapporo city.

* Corresponding author. Mailing address: Department of Microbiology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-ku, Sapporo 060-8556, Japan. Phone: 81-11-611-2111. Fax: 81-11-612-5861. E-mail: fujii{at}sapmed.ac.jp

{triangledown} Published ahead of print on 31 October 2007.

Journal of Clinical Microbiology, January 2008, p. 361-365, Vol. 46, No. 1
0095-1137/08/$08.00+0     doi:10.1128/JCM.01561-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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