This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, D.-M.
Right arrow Articles by Byun, J. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, D.-M.
Right arrow Articles by Byun, J. N.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, October 2008, p. 3465-3466, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00634-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effects of Antibiotic Treatment on the Results of Nested PCRs for Scrub Typhus{triangledown}

Dong-Min Kim1 and Joo Nam Byun2*

Division of Infectious Diseases, Department of Internal Medicine,1 Department of Radiology, Chosun University College of Medicine, Gwang-Ju, South Korea2

Received 3 April 2008/ Returned for modification 6 July 2008/ Accepted 7 August 2008

In order to determine the effects of antibiotic treatment on the results of nested PCRs for scrub typhus, we investigated the frequency of positive outcomes at various times after antibiotic administration in patients with scrub typhus. The rate of detection by nested PCR with blood buffy coat before antibiotic administration was 90.5%. However, this decreased to 60.5% within 3 days after administration of antibiotics such as doxycycline and rifampin and to 10% by the fourth day following antibiotic administration. Since the sensitivity of nested PCR can be affected by antibiotic administration, clinicians should perform this PCR before antibiotic administration and at the latest within 3 days after antibiotic administration.

* Corresponding author. Mailing address: Department of Radiology, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju 501-717, Republic of Korea. Phone: 82-62-220-3731. Fax: 82-62-234-9653. E-mail: jnbyun{at}chosun.ac.kr

{triangledown} Published ahead of print on 20 August 2008.

Journal of Clinical Microbiology, October 2008, p. 3465-3466, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00634-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»