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Journal of Clinical Microbiology, October 2008, p. 3477-3478, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00610-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Natamycin Susceptibility of Ocular Isolates of Fusarium and Aspergillus Species: Comparison of Commercially Formulated Natamycin Eye Drops to Pharmaceutical-Grade Powder{triangledown}

P. Lalitha,1 R. Vijaykumar,1 N. V. Prajna,2 and A. W. Fothergill3*

Department of Ocular Microbiology, Aravind Eye Hospital, Madurai, India,1 Department of Cornea, Aravind Eye Hospital, Madurai, India,2 Department of Pathology, University of Texas Health Sciences Center, San Antonio, Texas3

Received 31 March 2008/ Returned for modification 12 May 2008/ Accepted 31 July 2008

The Clinical and Laboratory Standards Institute susceptibility method prohibits the use of pharmacy preparations, but obtaining pure powders is difficult. The activity of natamycin against isolates of Aspergillus and Fusarium species isolated from keratitis was assessed by using both powder and pharmacy eye drop preparations. Eye drop preparations may be a viable option for testing natamycin activity.

* Corresponding author. Mailing address: University of Texas Health Science Center at San Antonio, 7780 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-6074. Fax: (210) 567-4076. E-mail: fothergill{at}uthscsa.edu

{triangledown} Published ahead of print on 13 August 2008.

Journal of Clinical Microbiology, October 2008, p. 3477-3478, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00610-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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