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Journal of Clinical Microbiology, October 2008, p. 3510-3513, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.01512-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Dynamics of the Mucosa-Associated Flora in Ulcerative Colitis Patients during Remission and Clinical Relapse {triangledown} ,{dagger}

Stephan J. Ott,1,2,{ddagger} Sophie Plamondon,3,{ddagger} Ailsa Hart,3 Alexander Begun,1,4 Ateequr Rehman,2 Michael A. Kamm,3,§* and Stefan Schreiber1,2,§*

Institute for Clinical Molecular Biology, Christian Albrechts University Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany,1 Clinic for General Internal Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany,2 St. Mark's Hospital, Watford Road, Harrow, HA1 3UJ Middlesex, London, United Kingdom,3 Institute for Medical Informatics and Statistics, Christian Albrechts University Kiel, Brunswikerstr. 10, 24105 Kiel, Germany4

Received 6 August 2008/ Accepted 7 August 2008

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.

* Corresponding author. Mailing address for Michael A. Kamm: St. Mark's Hospital, Watford Road, Harrow HA1 3UJ, United Kingdom. Phone: 0044 20 8235 4160. Fax: 0044 20 8235 4162. E-mail: kamm{at}ic.ac.uk. Mailing address for Stefan Schreiber: Clinic for General Internal Medicine, UKSH, Campus Kiel, and Institute for Clinical Molecular Biology, CAU Kiel, Schittenhelmstr. 12, 24105 Kiel, Germany. Phone: 0049 431 597 2350. Fax: 0049 431 597 1434. E-mail: s.schreiber{at}mucosa.de

{triangledown} Published ahead of print on 13 August 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

{ddagger} These authors contributed equally to the work.

§ These authors contributed equally to the work.

Journal of Clinical Microbiology, October 2008, p. 3510-3513, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.01512-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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