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Journal of Clinical Microbiology, October 2008, p. 3517-3521, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00641-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Dynamics and Determinants of Staphylococcus aureus Carriage in Infancy: the Generation R Study{triangledown}

Ankie Lebon,1,2,3 Joost A. M. Labout,1,2 Henri A. Verbrugh,3 Vincent W. V. Jaddoe,1,2,4 Albert Hofman,1,4 Willem van Wamel,3 Henriette A. Moll,1,2 and Alex van Belkum3*

The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands,1 Department of Pediatrics, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands,2 Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands,3 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands4

Received 4 April 2008/ Returned for modification 5 June 2008/ Accepted 22 July 2008

Serial nasal swabs were collected at the ages of 1.5, 6, and 14 months from 443 infants in the Generation R Study. The objective was to study the dynamics and determinants of Staphylococcus aureus nasal carriage in the first year of life. The prevalence of S. aureus carriage decreased in the first year of life, from 52.1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy.

* Corresponding author. Mailing address: Erasmus Medical Center-Department of Medical Microbiology and Infectious Diseases, Unit Research and Development, 's Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands. Phone: 31-107035813. Fax: 31-107033875. E-mail: a.vanbelkum{at}erasmusmc.nl

{triangledown} Published ahead of print on 30 July 2008.

Journal of Clinical Microbiology, October 2008, p. 3517-3521, Vol. 46, No. 10
0095-1137/08/$08.00+0     doi:10.1128/JCM.00641-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Lebon, A., Labout, J. A. M., Verbrugh, H. A., Jaddoe, V. W. V., Hofman, A., van Wamel, W. J. B., van Belkum, A., Moll, H. A. (2009). Role of Staphylococcus aureus Nasal Colonization in Atopic Dermatitis in Infants: The Generation R Study. Arch Pediatr Adolesc Med 163: 745-749 [Abstract] [Full Text]  


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