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Journal of Clinical Microbiology, November 2008, p. 3795-3797, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00684-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Nonutility of Repeat Laboratory Testing for Detection of Clostridium difficile by Use of PCR or Enzyme Immunoassay{triangledown}

Elisabeth Aichinger,1 Cathy D. Schleck,2 William S. Harmsen,2 Lisa M. Nyre,3 and Robin Patel1,3*

Division of Infectious Diseases,1 Division of Biostatistics,2 Division of Clinical Microbiology, College of Medicine, Mayo Clinic, Rochester, Minnesota 559053

Received 10 April 2008/ Returned for modification 30 May 2008/ Accepted 2 September 2008

The diagnostic gains of repeat testing for Clostridium difficile by enzyme immunoassay and PCR (i.e., initial negative result followed by positive result) within a 7-day period were 1.9 and 1.7%, respectively. There is little value of repeat testing for C. difficile by enzyme immunoassay or PCR.

* Corresponding author. Mailing address: Division of Clinical Microbiology, College of Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905. Phone: (507) 538-0579. Fax: (507) 284-4272. E-mail: patel.robin{at}mayo.edu

{triangledown} Published ahead of print on 10 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3795-3797, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.00684-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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