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Journal of Clinical Microbiology, November 2008, p. 3808-3810, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01782-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Serotype Distribution and Penicillin Resistance of Streptococcus pneumoniae Isolates from Middle Ear Fluids of Pediatric Patients with Acute Otitis Media in Japan {triangledown}

Muneki Hotomi,1 Dewan S. Billal,1 Yosuke Kamide,2 Keiko Kanesada,3 Yoshifumi Uno,4 Fumiyo Kudo,5 Masato Ito,6 Seiji Kakehata,7 Rinya Sugita,8 Masashi Ogami,1 Noboru Yamanaka,1* for the Advanced Treatment for Otitis Media Study Group (ATOMS)

Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan,1 Kamide ENT Clinic, Shizuoka, Japan,2 Nonohana Clinic, Yamaguchi, Japan,3 Uno ENT Clinic, Okayama, Japan,4 Chiba College of Public Health, Chiba, Japan,5 Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Kanazawa, Japan,6 Department of Otolaryngology, Head and Neck Surgery, Hirosaki, University, Hirosaki, Japan,7 Sugita ENT Clinic, Chiba, Japan8

Received 16 September 2008/ Accepted 18 September 2008

Out of 175 pneumococcal isolates from middle ear fluids, 26.3% were penicillin-resistant S. pneumoniae (PRSP). Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan.

* Corresponding author. Mailing address: Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama-shi, Wakayama 640-8501, Japan. Phone: 81-73-441-0651. Fax: 81-73-446-3846. E-mail: ynobi{at}wakayama-med.ac.jp

{triangledown} Published ahead of print on 1 October 2008.

Journal of Clinical Microbiology, November 2008, p. 3808-3810, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01782-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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