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Journal of Clinical Microbiology, November 2008, p. 3829-3832, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01440-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Thymidine-Dependent Staphylococcus aureus Small-Colony Variants: Human Pathogens That Are Relevant Not Only in Cases of Cystic Fibrosis Lung Disease {triangledown}

Silke Besier,1* Johannes Zander,1 Ekkehard Siegel,2 Stephan H. Saum,3 Klaus-Peter Hunfeld,1 Annabelle Ehrhart,1 Volker Brade,1 and Thomas A. Wichelhaus1

Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe-University, Frankfurt/Main, Germany,1 Institute of Medical Microbiology, Hospital of Johannes Gutenberg-University, Mainz, Germany,2 Institute of Molecular Biosciences, University, Frankfurt/Main, Germany3

Received 28 July 2008/ Returned for modification 31 August 2008/ Accepted 20 September 2008

We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Infection Control, Hospital of Johann Wolfgang Goethe-University, Frankfurt/Main, Paul-Ehrlich-Straße 40, 60596 Frankfurt/Main, Germany. Phone: 49 69 6301 6438. Fax: 49 69 6301 5767. E-mail: s.besier{at}em.uni-frankfurt.de

{triangledown} Published ahead of print on 1 October 2008.

Journal of Clinical Microbiology, November 2008, p. 3829-3832, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01440-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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