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Journal of Clinical Microbiology, November 2008, p. 3856-3859, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01122-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Three-Class-Resistant Human Immunodeficiency Virus Type 1 Variant in a Drug-Naive Heterosexual Couple{triangledown}

Francesca Razzolini,1 Francesco Saladini,1 Lisa Malincarne,2 Ilaria Vicenti,1 Nicola Palladino,2 Laura Romano,1 Daniela Francisci,2 and Maurizio Zazzi1*

Section of Microbiology, Department of Molecular Biology, University of Siena, Siena, Italy,1 Division of Infectious Diseases, University of Perugia, Perugia, Italy2

Received 12 June 2008/ Returned for modification 15 August 2008/ Accepted 14 September 2008

Combination antiretroviral treatment was initiated in a heterosexual couple newly diagnosed with human immunodeficiency virus type 1 infection. Multiple genotypic drug resistance testing following early rebound of viral load revealed that the same three-class-resistant human immunodeficiency virus type 1 strain had been present in both patients since before initiation of treatment.

* Corresponding author. Mailing address: Section of Microbiology, Department of Molecular Biology, University of Siena, Viale Bracci 1, I-53100 Siena, Italy. Phone: 39 0577 233850. Fax: 39 0577 233870. E-mail: zazzi{at}unisi.it

{triangledown} Published ahead of print on 24 September 2008.

Journal of Clinical Microbiology, November 2008, p. 3856-3859, Vol. 46, No. 11
0095-1137/08/$08.00+0     doi:10.1128/JCM.01122-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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