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Journal of Clinical Microbiology, December 2008, p. 4071-4074, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.01088-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of the Disk Diffusion Method Compared to the Microdilution Method in Susceptibility Testing of Anidulafungin against Filamentous Fungi{triangledown}

Carmelo Massimo Maida,1 Maria Eleonora Milici,1 Laura Trovato,2 Salvatore Oliveri,2 Emanuele Amodio,1 Elisabetta Spreghini,3 Giorgio Scalise,3 and Francesco Barchiesi3*

Dipartimento di Scienze per la Promozione della Salute-sezione di Microbiologia, Università di Palermo, Palermo, Italy,1 Dipartimento di Scienze Microbiologiche e Scienze Ginecologiche, Università di Catania, Catania, Italy,2 Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Ancona, Italy3

Received 9 June 2008/ Returned for modification 25 July 2008/ Accepted 2 October 2008

Susceptibility testing of anidulafungin (AFG) against 32 mold isolates showed an excellent correlation between disk diffusion (DD) and broth microdilution methods. Based on our data, a 2-µg disk of AFG and a 24-h reading time might represent the best parameters for AFG DD testing against filamentous fungi.

* Corresponding author. Mailing address: Istituto di Malattie Infettive e Medicina Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera-Universitaria, Ospedali Riuniti, Umberto I—G.M. Lancisi—G. Salesi, Via Conca 60020, Torrette di Ancona, Ancona, Italy. Phone: 39 0715963426. Fax: 39 071 5963468. E-mail: f.barchiesi{at}univpm.it

{triangledown} Published ahead of print on 15 October 2008.

Journal of Clinical Microbiology, December 2008, p. 4071-4074, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.01088-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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