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Journal of Clinical Microbiology, December 2008, p. 4075-4077, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.00822-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates in China{triangledown} ,{dagger}

Zhaogang Sun,1,{ddagger} Yanjie Chao,2,{ddagger} Xuxia Zhang,1 Jianyuan Zhang,1 Yan Li,1 Yunqing Qiu,1 Yi Liu,1 Lihui Nie,1 Aizhen Guo,2 and Chuanyou Li1*

Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing 101149, China,1 The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China2

Received 30 April 2008/ Returned for modification 29 June 2008/ Accepted 15 October 2008

Thirteen extensively drug-resistant tuberculosis isolates which were highly resistant to a broad spectrum of antituberculosis drugs were identified from 1,926 clinical isolates in China. They had highly diverse mycobacterial interspersed repetitive-unit-variable-number tandem-repeat patterns. Most, but not all, of the drug target genes had mutations contributing to resistance to the corresponding drug.

* Corresponding author. Mailing address: Department of Bacteriology and Immunology, Beijing Tuberculosis & Thoracic Tumor Research Institute, Tongzhou District, Beijing 101149, China. Phone: 86-10-69545354. Fax: 86-10-69546819. E-mail: lichuanyou6688{at}hotmail.com

{triangledown} Published ahead of print on 22 October 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

{ddagger} Z. Sun and Y. Chao contributed equally to this work.

Journal of Clinical Microbiology, December 2008, p. 4075-4077, Vol. 46, No. 12
0095-1137/08/$08.00+0     doi:10.1128/JCM.00822-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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