This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lukashev, A. N.
Right arrow Articles by Gmyl, L. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lukashev, A. N.
Right arrow Articles by Gmyl, L. V.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, February 2008, p. 665-670, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.02386-06
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Analysis of Echovirus 30 Isolates from Russia and New Independent States Revealing Frequent Recombination and Reemergence of Ancient Lineages{triangledown}

Alexander N. Lukashev,1,2* Olga E. Ivanova,1 Tatiana P. Eremeeva,1 and Larisa V. Gmyl1

Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia,1 Bute Medical School, University of St Andrews, Scotland, United Kingdom2

Received 27 November 2006/ Returned for modification 31 October 2007/ Accepted 27 November 2007

We studied two genome regions, VP1 and 3D, of 48 echovirus 30 (E30) isolates from Russia and the new independent states. In VP1, most isolates were similar to European strains reported earlier, and frequent change of circulating subgroups was noticed. We also observed, in 2003-2006, the reemergence of a group of E30 strains with a VP1 region very distant from most modern E30 strains and remotely similar to E30 isolates from the 1960s and the 1970s. A study of the 3D genome region detected multiple recombination events among the studied strains. Recombination presumably occurred every few years, and therefore, the study of a single VP1 genome region cannot accurately describe the phylogenetic history of the virus or predict pathogenetic properties of an isolate. In general, a comparison of the VP1 and 3D genome region phylogenies revealed, in some instances, virtually independent circulation of enterovirus genome fragments on a scale of years.

* Corresponding author. Mailing address: Bute Medical School, University of St Andrews, St Andrews, Fife, Scotland, KY16 9TS, United Kingdom. Phone: 44-01334-467191. Fax: 44-01334-462595. E-mail: Alexander_lukashev{at}hotmail.com

{triangledown} Published ahead of print on 12 December 2007.

Journal of Clinical Microbiology, February 2008, p. 665-670, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.02386-06
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Leitch, E. C. M., Bendig, J., Cabrerizo, M., Cardosa, J., Hyypia, T., Ivanova, O. E., Kelly, A., Kroes, A. C. M., Lukashev, A., MacAdam, A., McMinn, P., Roivainen, M., Trallero, G., Evans, D. J., Simmonds, P. (2009). Transmission Networks and Population Turnover of Echovirus 30. J. Virol. 83: 2109-2118 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»