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Journal of Clinical Microbiology, February 2008, p. 740-742, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01981-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Cervical Human Papillomavirus (HPV) Infection in South African Women: Implications for HPV Screening and Vaccine Strategies

Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa,¹ School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, South Africa,² National Health Laboratory Service, Groote Schuur Hospital, Observatory, Cape Town, South Africa³

Received 8 October 2007/ Accepted 17 October 2007

The prevalence of cervical human papillomavirus (HPV) in South African women (n = 1,073) increased from 20.4% (173/848) in women with normal cytology to 41.7% (48/115) in women with atypical squamous cells of undetermined significance, 70.2% (40/57) in women with low-grade squamous intraepithelial lesions, and 83% (44/53) in women with high-grade squamous intraepithelial lesions (HSILs). HPV types 16 and 35 were the dominant types in women with HSILs but not in women in the other categories.

Published ahead of print on 31 October 2007.