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Journal of Clinical Microbiology, February 2008, p. 747-749, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01781-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

In Vitro Bactericidal Activity of Streptococcus pneumoniae and Bactericidal Susceptibility of Staphylococcus aureus Strains Isolated from Cocolonized versus Noncocolonized Children{triangledown}

Gili Regev-Yochay,1,2* Richard Malley,2 Ethan Rubinstein,3 Meir Raz,4 Ron Dagan,5 and Marc Lipsitch1

Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts,1 Division of Infectious Diseases, Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts,2 Infectious Diseases Section, University of Manitoba, Winnipeg, Manitoba, Canada,3 Hashfela District, Macabbi Healthcare Services, Rishon-Lezion, Israel,4 Pediatric Infectious Disease Unit, Soroka University Medical Center, and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel5

Received 6 September 2007/ Returned for modification 16 October 2007/ Accepted 5 November 2007

Streptococcus pneumoniae is bactericidal to Staphylococcus aureus in vitro. To determine whether this in vitro effect accounts for the inverse relation between S. pneumoniae and S. aureus colonization reported in previous epidemiologic studies, we compared S. pneumoniae and S. aureus strains from cocolonized children to those from noncocolonized children. Cocolonizing pneumococci were less bactericidal and cocolonizing staphylococci less susceptible to this effect; however, the magnitude of the effect was small. Thus, in vitro killing is not the major determinant of the pattern of cocolonization.

* Corresponding author. Mailing address: Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115. Phone: (617) 432-3269. Fax: (617) 566-7805. E-mail: gregev{at}hsph.harvard.edu

{triangledown} Published ahead of print on 26 November 2007.

Journal of Clinical Microbiology, February 2008, p. 747-749, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01781-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Margolis, E. (2009). Hydrogen Peroxide-Mediated Interference Competition by Streptococcus pneumoniae Has No Significant Effect on Staphylococcus aureus Nasal Colonization of Neonatal Rats. J. Bacteriol. 191: 571-575 [Abstract] [Full Text]  


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