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Journal of Clinical Microbiology, February 2008, p. 750-753, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01587-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Molecular Characterization of Three New Virulent Newcastle Disease Virus Variants Isolated in China

Institute of Poultry Science, Shandong Academy of Agricultural Sciences, Jinan 250100, China,¹ Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China,² College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, China³

Received 9 August 2007/ Returned for modification 16 October 2007/ Accepted 13 November 2007

Three cases of Newcastle disease virus (NDV) found in nature had the lentogenic motif ¹¹²G-R-Q-G-R-L¹¹⁷ in their fusion protein cleavage sites. However, both intracerebral pathogenicity and intravenous pathogenicity indexes showed that these NDV isolates were virulent. In comparison with the LaSota live virus vaccine, these viruses had significant genetic variations in the hemagglutinin-neuraminidase gene.

Published ahead of print on 5 December 2007.