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Journal of Clinical Microbiology, February 2008, p. 807-809, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01963-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Heterogeneity of Hemolysin Expression during Neonatal Streptococcus agalactiae Sepsis{triangledown}

Anja Sigge,1 Manuel Schmid,2 Stefanie Mauerer,1 and Barbara Spellerberg1*

Institute of Medical Microbiology and Hygiene, Robert Koch Str. 8, Ulm D-89081, Germany,1 University Children's Hospital, Ulm, Eythstr. 24, Ulm D-89081, Germany2

Received 4 October 2007/ Returned for modification 3 November 2007/ Accepted 26 November 2007

The β-hemolysin of Streptococcus agalactiae is a major virulence factor; consequently, nonhemolytic strains rarely cause infections. We report on a case of neonatal sepsis caused by a strain displaying heterogeneous hemolysin expression. It was detected by the simultaneous isolation of hemolytic and nonhemolytic colonies from cultures of the infant's blood.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, University of Ulm, Robert Koch Str. 8, Ulm D-89081, Germany. Phone: (49)-731-50065333. Fax: (49)-731-50065302. E-mail: barbara.spellerberg{at}uniklinik-ulm.de

{triangledown} Published ahead of print on 12 December 2007.

Journal of Clinical Microbiology, February 2008, p. 807-809, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01963-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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