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Journal of Clinical Microbiology, February 2008, p. 821-823, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01132-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Brain Abscess Caused by Streptomyces Infection following Penetration Trauma: Case Report and Results of Susceptibility Analysis of 92 Isolates of Streptomyces Species Submitted to the CDC from 2000 to 2004{triangledown}

Charles E. Rose III,1* June M. Brown,2 and John F. Fisher1

Department of Medicine, Medical College of Georgia, Augusta, Georgia,1 Bacterial Zoonoses Branch, Division of Foodborne, Bacterial and Mycotic Diseases, National Center for Zoonotic, Vector-borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303332

Received 6 June 2007/ Returned for modification 20 August 2007/ Accepted 13 December 2007

The case of a patient who presented with a brain abscess caused by Streptomyces infection following penetrating cerebral trauma with a soil-contaminated object generated an interest in optimizing antimicrobial therapy. Collaboration with the Centers for Disease Control and Prevention led to the analysis of susceptibility data for Streptomyces isolates that suggested that amikacin (100% susceptibility for 92 isolates tested) and linezolid, an oxazolidinone (100% susceptibility for 41 isolates tested), offer reliable activity against all isolates.

* Corresponding author. Mailing address: Medical College of Georgia, BA 5300, 15th Street, Augusta, GA 30912. Phone: (706) 721-4448. Fax: (706) 721-4517. E-mail: crose{at}mcg.edu

{triangledown} Published ahead of print on 19 December 2007.

Journal of Clinical Microbiology, February 2008, p. 821-823, Vol. 46, No. 2
0095-1137/08/$08.00+0     doi:10.1128/JCM.01132-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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