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Journal of Clinical Microbiology, March 2008, p. 1113-1115, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.02107-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Novel Loop-Mediated Isothermal Amplification Method for Detection of the JP2 Clone of Aggregatibacter actinomycetemcomitans in Subgingival Plaque{triangledown}

Mitsuko Seki,1,2 Knud Poulsen,1 Dorte Haubek,3 and Mogens Kilian1*

Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark,1 Department of Oral Health Sciences, Nihon University School of Dentistry, Tokyo, Japan,2 Department of Community Oral Health and Pediatric Dentistry, University of Aarhus, Aarhus, Denmark3

Received 1 November 2007/ Accepted 16 December 2007

We developed a loop-mediated isothermal amplification method that detects the JP2 clone of Aggregatibacter actinomycetemcomitans, which induces aggressive periodontitis in adolescents of North and West African descents. Being independent of special equipment, this specific and sensitive method offers significant advantages for screening of patients on a population basis and in clinical settings.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark. Phone: (45) 89421735. Fax: (45) 89196128. E-mail: kilian{at}microbiology.au.dk

{triangledown} Published ahead of print on 26 December 2007.

Journal of Clinical Microbiology, March 2008, p. 1113-1115, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.02107-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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