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Journal of Clinical Microbiology, March 2008, p. 1116-1117, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.01188-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increasing Prevalence of Toxin A-Negative, Toxin B-Positive Isolates of Clostridium difficile in Korea: Impact on Laboratory Diagnosis{triangledown}

Heejung Kim,1 Thomas V. Riley,2 Myungsook Kim,1 Chang Ki Kim,1 Dongeun Yong,1 Kyungwon Lee,1* Yunsop Chong,1 and Jong-Woo Park3

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea,1 Microbiology and Immunology, The University of Western Australia, Perth, Western Australia,2 Department of Laboratory Medicine, Chungnam National University, College of Medicine, Daejeon, Korea3

Received 13 June 2007/ Returned for modification 20 August 2007/ Accepted 8 January 2008

Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A– B+). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A– B+ strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.

* Corresponding author. Mailing address: Department of Laboratory Medicine, Yonsei University College of Medicine, 134 Shinchondong, Seodaemunku, Seoul 120-752, Korea. Phone: 82-2-2228-2446. Fax: 82-2-313-0908. E-mail: leekcp{at}yumc.yonsei.ac.kr

{triangledown} Published ahead of print on 16 January 2008.

Journal of Clinical Microbiology, March 2008, p. 1116-1117, Vol. 46, No. 3
0095-1137/08/$08.00+0     doi:10.1128/JCM.01188-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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