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Journal of Clinical Microbiology, April 2008, p. 1466-1469, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02241-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Optimal Method of Collection of First-Void Urine for Diagnosis of Chlamydia trachomatis Infection in Men{triangledown}

Craig A. Wisniewski,1 John A. White,2 Claude-Edouard C. Michel,1 Lourdes Mahilum-Tapay,1,{dagger} Jose Paolo V. Magbanua,1 Elpidio Cesar B. Nadala Jr.,1,{dagger} Penelope J. Barber,3 Beng T. Goh,4 and Helen H. Lee1*

Department of Haematology, University of Cambridge, Cambridge CB2 2PT,1 Department of Genitourinary Medicine, St. Thomas' Hospital, Lambeth Palace Road, London SE1 7EH,2 Brook Advisory Centre, Birmingham B1 1BL,3 Barts and the Royal London NHS Trust, Whitechapel, London E1 1BB, United Kingdom4

Received 20 November 2007/ Returned for modification 4 January 2008/ Accepted 23 January 2008

First-void urine (FVU) is the preferred specimen for the diagnosis of urogenital Chlamydia trachomatis infection in men. We have developed FirstBurst, a urine collection device that collects the first 4 to 5 ml of FVU and yields a specimen with a sixfold higher C. trachomatis organism load than the regular urine cup by quantitative PCR (32,533 versus 5,271 plasmids/ml; P < 0.0001). Consequently, the use of FirstBurst to collect a urine sample improved the sensitivity of a rapid test for Chlamydia over testing of samples collected with a urine cup (82 versus 47% sensitivity using PCR as a reference; P < 0.0015).

* Corresponding author. Mailing address: Department of Haematology, University of Cambridge, EABC Site, Long Road, Cambridge CB2 2PT, United Kingdom. Phone: 44-1223-548080. Fax: 44-1223-242044. E-mail: hl207{at}cam.ac.uk

{triangledown} Published ahead of print on 30 January 2008.

{dagger} Present address: Diagnostics for the Real World Ltd., 840 Del Rey Avenue, Sunnyvale, CA 94085.

Journal of Clinical Microbiology, April 2008, p. 1466-1469, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02241-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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