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Journal of Clinical Microbiology, April 2008, p. 1498-1500, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02117-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Validation of the BrockTB Stat-Pak Assay for Detection of Tuberculosis in Eurasian Badgers (Meles meles) and Influence of Disease Severity on Diagnostic Accuracy{triangledown}

Mark A. Chambers,1* Tim Crawshaw,2 Sue Waterhouse,3 Richard Delahay,4 R. Glyn Hewinson,1 and Konstantin P. Lyashchenko5

TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Surrey KT15 3NB, United Kingdom,1 Veterinary Laboratories Agency Starcross, Staplake Mount, Exeter, Devon EX6 8PE, United Kingdom,2 Veterinary Laboratories Agency Langford, Bristol BS40 5DX, United Kingdom,3 Central Science Laboratory, Sand Hutton, York YO4 1LZ, United Kingdom,4 Chembio Diagnostic Systems, Inc., Medford, New York 117635

Received 2 November 2007/ Accepted 4 February 2008

A lateral-flow immunoassay (BrockTB Stat-Pak) for detecting tuberculosis in Eurasian badgers was 49% sensitive and 93% specific against culture for M. bovis (n = 1,464) at necropsy. However, the sensitivity was significantly higher (66 to 78%) in animals with more severe tuberculosis, indicating that the BrockTB Stat-Pak may be useful for the detection of badgers with the greatest risk of transmitting disease.

* Corresponding author. Mailing address: TB Research Group, Department of Statutory and Exotic Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Surrey KT15 3NB, United Kingdom. Phone: 44 1932 357 494. Fax: 44 1932 357 260. E-mail: m.a.chambers{at}vla.defra.gsi.gov.uk

{triangledown} Published ahead of print on 13 February 2008.

Journal of Clinical Microbiology, April 2008, p. 1498-1500, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02117-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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