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Journal of Clinical Microbiology, April 2008, p. 1514-1516, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01938-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Spread of a Low-Fitness Drug-Resistant Mycobacterium tuberculosis Strain in a Setting of High Human Immunodeficiency Virus Prevalence{triangledown}

O. J. Strauss,1 R. M. Warren,1* A. Jordaan,1 E. M. Streicher,1 M. Hanekom,1 A. A. Falmer,1 H. Albert,2 A. Trollip,2 E. Hoosain,3 P. D. van Helden,1 and T. C. Victor1

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South Africa,1 Biotec Laboratories, Ltd., c/o National Health Laboratory Service, Cape Town, Western Cape, South Africa,2 Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape, South Africa3

Received 2 October 2007/ Returned for modification 23 December 2007/ Accepted 4 February 2008

The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.


* Corresponding author. Mailing address: DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/ MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 021 938 9073. Fax: 021 938 9476. E-mail: rw1{at}sun.ac.za

{triangledown} Published ahead of print on 13 February 2008.


Journal of Clinical Microbiology, April 2008, p. 1514-1516, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01938-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.




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