JCM Figure table search 04
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
JCM.01938-07v1
46/4/1514    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Strauss, O. J.
Right arrow Articles by Victor, T. C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strauss, O. J.
Right arrow Articles by Victor, T. C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2008, p. 1514-1516, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01938-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Spread of a Low-Fitness Drug-Resistant Mycobacterium tuberculosis Strain in a Setting of High Human Immunodeficiency Virus Prevalence{triangledown}

O. J. Strauss,1 R. M. Warren,1* A. Jordaan,1 E. M. Streicher,1 M. Hanekom,1 A. A. Falmer,1 H. Albert,2 A. Trollip,2 E. Hoosain,3 P. D. van Helden,1 and T. C. Victor1

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, Western Cape, South Africa,1 Biotec Laboratories, Ltd., c/o National Health Laboratory Service, Cape Town, Western Cape, South Africa,2 Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape, South Africa3

Received 2 October 2007/ Returned for modification 23 December 2007/ Accepted 4 February 2008

The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations.

* Corresponding author. Mailing address: DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/ MRC Centre for Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, P.O. Box 19063, Tygerberg 7505, South Africa. Phone: 021 938 9073. Fax: 021 938 9476. E-mail: rw1{at}sun.ac.za

{triangledown} Published ahead of print on 13 February 2008.

Journal of Clinical Microbiology, April 2008, p. 1514-1516, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01938-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.