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Journal of Clinical Microbiology, April 2008, p. 1517-1519, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02046-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of the Abbott RealTime HBV DNA Assay and Comparison to the Cobas AmpliPrep/Cobas TaqMan 48 Assay in Monitoring Patients with Chronic Cases of Hepatitis B{triangledown}

Marco Ciotti,1* Fabbio Marcuccilli,1 Tania Guenci,1 Maria Grazia Prignano,2 and Carlo Federico Perno1

Laboratory of Clinical Microbiology and Virology, University Hospital Tor Vergata, Viale Oxford, 81-00133 Rome, Italy,1 IRCCS IFO-San Gallicano Institute, Rome, Italy2

Received 19 October 2007/ Returned for modification 25 January 2008/ Accepted 1 February 2008

The new Abbott RealTime hepatitis B virus (HBV) assay was compared to the Cobas AmpliPrep/Cobas TaqMan assay with 128 serum samples from patients with chronic hepatitis B. There was an excellent correlation (r = 0.961) between the two assays, with the Abbott RealTime test showing at least equivalent sensitivity and a slightly wider dynamic range than the Cobas TaqMan assay. By coupling high sensitivity with a large dynamic range, the Abbott RealTime HBV assay is useful in monitoring the response to antiviral therapy.

* Corresponding author. Mailing address: Laboratory of Clinical Microbiology and Virology, University Hospital Tor Vergata, Viale Oxford, 81-00133 Rome, Italy. Phone: 39 0620902087. Fax: 39 0620902078. E-mail: marco.ciotti{at}ptvonline.it

{triangledown} Published ahead of print on 13 February 2008.

Journal of Clinical Microbiology, April 2008, p. 1517-1519, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.02046-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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