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Journal of Clinical Microbiology, April 2008, p. 1530-1533, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01964-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1{triangledown} ,{dagger}

Thomas Åkerlund,1* Ingela Persson,1 Magnus Unemo,2 Torbjörn Norén,3 Bo Svenungsson,4 Marlene Wullt,5 and Lars G. Burman1

Department of Bacteriology, Swedish Institute for Infectious Disease Control, Solna, Sweden,1 Department of Clinical Microbiology,2 Department of Infectious Diseases, Örebro University Hospital, Örebro, Sweden,3 Department of Communicable Disease Control and Prevention, Karolinska University Hospital, Stockholm, Sweden,4 Department of Clinical Sciences, Infectious Disease Research Unit, Malmö University Hospital, Lund University, Malmö, Sweden5

Received 4 October 2007/ Returned for modification 15 November 2007/ Accepted 8 February 2008

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the same tcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.

* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, Department of Bacteriology, SE-171 82, Solna, Sweden. Phone: 46 8 4572467. Fax: 46 8 301797. E-mail: Thomas.Akerlund{at}smi.ki.se

{triangledown} Published ahead of print on 20 February 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

Journal of Clinical Microbiology, April 2008, p. 1530-1533, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01964-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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