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Journal of Clinical Microbiology, April 2008, p. 1548-1550, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01040-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CASE REPORT

Acute Renal Failure Due to Acute Tubular Necrosis Caused by Direct Invasion of Orientia tsutsugamushi{triangledown}

Dong-Min Kim,1 Dae Woong Kang,1 Jong O. Kim,1 Jong Hoon Chung,1 Hyun Lee Kim,1* Chi Young Park,1 and Sung-Chul Lim2

Division of Infectious Diseases, Department of Internal Medicine,1 Department of Pathology and Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju-si, South Korea2

Received 21 May 2007/ Returned for modification 5 September 2007/ Accepted 31 October 2007

We describe a scrub typhus patient with acute renal failure for whom a diagnosis was made based on serology as well as immunohistochemical (IHC) staining and an electron microscopic examination (EM) of a renal biopsy specimen. For our case, we demonstrated by IHC staining and EM that renal failure was caused by acute tubular necrosis due to a direct invasion of Orientia tsutsugamushi.

* Corresponding author. Mailing address: Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju 501-717, South Korea. Phone: 82-62-220-3178. Fax: 82-62-234-9653. E-mail: hyunkim{at}chosun.ac.kr

{triangledown} Published ahead of print on 14 November 2007.

Journal of Clinical Microbiology, April 2008, p. 1548-1550, Vol. 46, No. 4
0095-1137/08/$08.00+0     doi:10.1128/JCM.01040-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sonthayanon, P., Chierakul, W., Wuthiekanun, V., Phimda, K., Pukrittayakamee, S., Day, N. P., Peacock, S. J. (2009). Association of High Orientia tsutsugamushi DNA Loads with Disease of Greater Severity in Adults with Scrub Typhus. J. Clin. Microbiol. 47: 430-434 [Abstract] [Full Text]  


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