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Journal of Clinical Microbiology, May 2008, p. 1881-1884, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.01875-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Agammaglobulinemia and Staphylococcus aureus Botryomycosis in a Cohort of Related Sentinel Swiss Webster Mice{triangledown}

Erin C. Bridgeford,* James G. Fox, Prashant R. Nambiar, and Arlin B. Rogers

Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 16-825, Cambridge, Massachusetts 02139

Received 20 September 2007/ Returned for modification 20 November 2007/ Accepted 27 February 2008

Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation in surveillance programs.

* Corresponding author. Mailing address: Division of Comparative Medicine 16-825, Massachusetts Institute of Technology, Cambridge, MA 02139. Phone: (617) 253-9438. Fax: (617) 258-5708. E-mail: ecbridge{at}mit.edu

{triangledown} Published ahead of print on 5 March 2008.

Journal of Clinical Microbiology, May 2008, p. 1881-1884, Vol. 46, No. 5
0095-1137/08/$08.00+0     doi:10.1128/JCM.01875-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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