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Journal of Clinical Microbiology, June 2008, p. 2066-2069, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.02038-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Detection of the Klebsiella pneumoniae Carbapenemase Type 2 Carbapenem-Hydrolyzing Enzyme in Clinical Isolates of Citrobacter freundii and K. oxytoca Carrying a Common Plasmid{triangledown}

J. Kamile Rasheed,1* James W. Biddle,1 Karen F. Anderson,1 Laraine Washer,2 Carol Chenoweth,2 John Perrin,2 Duane W. Newton,2 and Jean B. Patel1

Division of Healthcare Quality Promotion, National Center for the Prevention, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 University of Michigan Hospitals and Health Centers, Ann Arbor, Michigan 481092

Received 18 October 2007/ Returned for modification 15 January 2008/ Accepted 23 March 2008

The Klebsiella pneumoniae carbapenemase (KPC) was detected in carbapenem-resistant isolates of Citrobacter freundii and Klebsiella oxytoca recovered from different patients in a Michigan hospital. Restriction analysis and hybridization with a KPC-specific probe showed the blaKPC-2 genes of these two genera of the family Enterobacteriaceae are carried on a common plasmid.

* Corresponding author. Mailing address: Anti-Infectives Investigation Section (G08), Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333. Phone: (404) 639-3247. Fax: (404) 639-1381. E-mail: jkr1{at}cdc.gov

{triangledown} Published ahead of print on 2 April 2008.

Journal of Clinical Microbiology, June 2008, p. 2066-2069, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.02038-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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