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Journal of Clinical Microbiology, June 2008, p. 2099-2101, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00194-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Outbreak of OXY-2-Producing Klebsiella oxytoca in a Renal Transplant Unit{triangledown}

Mariela Soledad Zárate,1* Ana C. Gales,3 Renata C. Picão,3 Gervasio Soler Pujol,2 Alejandra Lanza,1 and Jorgelina Smayevsky1

Laboratorio de Bacteriología, Micología y Parasitología,1 Sección de Nefrología, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Ciudad Autónoma de Buenos Aires, Argentina,2 Laboratorio ALERTA, Disciplina de Infectologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil3

Received 30 January 2008/ Returned for modification 4 April 2008/ Accepted 9 April 2008

We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal β-lactamase hyperproduction was caused by a point mutation in the blaOXY-2 gene promoter region.

* Corresponding author. Mailing address: Guemes 3066 1° Dpto. 4, CP1425, Buenos Aires, Argentina. Phone: 54-11-15-54999139. Fax: 54-11-4822-6588. E-mail: sole_z{at}hotmail.com

{triangledown} Published ahead of print on 16 April 2008.

Journal of Clinical Microbiology, June 2008, p. 2099-2101, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.00194-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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