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Journal of Clinical Microbiology, June 2008, p. 2125-2128, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.02484-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Is the Sequenced Bordetella pertussis Strain Tohama I Representative of the Species?{triangledown}

Valérie Caro,* Valérie Bouchez, and Nicole Guiso

Institut Pasteur, Molecular Prevention and Therapy of Human Diseases Unit, URA-CNRS 3012, National Center of Reference of Whooping Cough and other Bordetelloses, Paris, France

Received 28 December 2007/ Returned for modification 10 March 2008/ Accepted 24 March 2008

Subtractive hybridization was carried out to identify differences between the sequenced genome of Bordetella pertussis Tohama I and those of two recently collected isolates. We identified genetic regions specific to recent isolates, old isolates, and isolates of B. parapertussis and B. bronchiseptica species. We conclude that Tohama I strain is not representative of the B. pertussis species.

* Corresponding author. Mailing address: Institut Pasteur, Unité PTMMH, URA-CNRS 3012, National Center of Reference of Whooping Cough and other Bordetelloses, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France. Phone: 33 (0)1 45 68 80 05. Fax: 33 (0)1 40 61 35 33. E-mail: vcaro{at}pasteur.fr

{triangledown} Published ahead of print on 2 April 2008.

Journal of Clinical Microbiology, June 2008, p. 2125-2128, Vol. 46, No. 6
0095-1137/08/$08.00+0     doi:10.1128/JCM.02484-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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