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Journal of Clinical Microbiology, July 2008, p. 2389-2392, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.00053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Detection of Caspofungin Resistance in Candida spp. by Etest{triangledown}

Marie Desnos-Ollivier,1 Françoise Dromer,1 and Eric Dannaoui1,2*

Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 75724 Paris Cedex 15,1 Université Paris Descartes, Faculté de Médecine, AP-HP, Hôpital Européen Georges Pompidou, Unité de Parasitologie-Mycologie, 75015 Paris, France2

Received 10 January 2008/ Returned for modification 27 February 2008/ Accepted 21 April 2008

The caspofungin susceptibilities of 28 Candida sp. clinical isolates, including 8 caspofungin-resistant isolates characterized by mutations in the Fks1 protein, were determined by the Etest in RPMI and AM3 media. Good discrimination between wild-type and mutant isolates was obtained. These results suggest that the Etest is valuable for the detection of caspofungin resistance in Candida spp.

* Corresponding author. Mailing address: Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25, rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 40 61 32 50. Fax: 33 1 45 68 84 20. E-mail: dannaoui{at}pasteur.fr

{triangledown} Published ahead of print on 30 April 2008.

Journal of Clinical Microbiology, July 2008, p. 2389-2392, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.00053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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