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Journal of Clinical Microbiology, July 2008, p. 2418-2422, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.00368-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Prevalence and Sequence Diversity of a Factor Required for Actin-Based Motility in Natural Populations of Burkholderia Species{triangledown} ,{dagger}

Chayada Sitthidet,1,{ddagger} Joanne M. Stevens,2,{ddagger} Narisara Chantratita,3 Bart J. Currie,4 Sharon J. Peacock,3 Sunee Korbsrisate,1* and Mark P. Stevens2

Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand,1 Division of Microbiology, Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, United Kingdom,2 Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajvithi Road, Bangkok 10400, Thailand,3 Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia4

Received 23 February 2008/ Returned for modification 15 April 2008/ Accepted 13 May 2008

Actin-based motility of the melioidosis pathogen Burkholderia pseudomallei requires BimA. We report a high degree of conservation of bimA in 99 B. pseudomallei isolates from the area of endemicity. A geographically restricted subset of B. pseudomallei isolates harbored a B. mallei-like bimA allele (12.1%), confounding a differential diagnostic test based on amplification of species-specific bimA regions.

* Corresponding author. Mailing address: Department of Immunology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Pran-nok Road, Bangkoknoi, Bangkok 10700, Thailand. Phone: 66-2-418-0569. Fax: 66-2-418-1636. E-mail: grsks{at}mahidol.ac.th

{triangledown} Published ahead of print on 21 May 2008.

{dagger} Supplemental material for this article may be found at http://jcm.asm.org/.

{ddagger} These authors contributed equally to this study.

Journal of Clinical Microbiology, July 2008, p. 2418-2422, Vol. 46, No. 7
0095-1137/08/$08.00+0     doi:10.1128/JCM.00368-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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